202090197. A method is proposed for the preparation of tapentadol in the form of a base or its hydrochloride, including the preparation of salt (III) from a mixture of diastereomers (II) by crystallization-induced asymmetric transformation (CIAT), by means of oxo-enol tautomeric equilibrium of covalently linked diastereomers shifted towards the desired diastereomer, without using chiral separation with. 202090197

 
 A method is proposed for the preparation of tapentadol in the form of a base or its hydrochloride, including the preparation of salt (III) from a mixture of diastereomers (II) by crystallization-induced asymmetric transformation (CIAT), by means of oxo-enol tautomeric equilibrium of covalently linked diastereomers shifted towards the desired diastereomer, without using chiral separation with202090197  X 96 in

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